Successful milestones

• De- and recellularization of a blood vessel (a vein without valves) using bone-marrow stem cells

• Developing solutions and media needed to facilitate the de- and recellularization process

• Adaptation of the de-/recellularization technique to veins with valves

• Development of a refined procedure for recellularizing blood vessels, which is now ready for scale up in a regulatory correct environment (GMP)

• Development of a technique for isolation of stem cells from peripheral whole blood

• Successful transplantation of tissue engineered blood vessels to 3 pedriatric patients

Future milestones

• Further development of the technique of using peripheral blood stem cells

• Applying the technology to develop also tissue-engineered arteries

• GMP accreditation of the production of media and solutions for the de- and recellularization of blood vessels

• GMP accreditation of the process for developing recellularized blood vessels

• Performing a clinical study with Personalized Tissue Engineered Veins (P-TEV)

• Establishing a regulatory roadmap

• Scaling production of tissue-engineered veins and arteries