NovaHep is a biotechnology company – a pioneer within the field of regenerative medicine, developing stem cell technology for generating human tissues that can be used in reconstructive surgery or for toxicity and biocompatibility studies. The main area of focus…
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Carcinogenesis
Background Although rodent models offer the advantage of parallel in vitro and in vivo studies, human cell culture models are designed to study mechanisms of human carcinogenesis more directly. Prerequisites for human cell transformation model development are long-term growth of human cells in culture, sensitivity of…
Human Cell Culture
Recent findings in human cell cultures in vitro and in rats in vivo indicate that tungsten may have a synergistic effect with cobalt or nickel leading to tumorigenicity (Miller et al., 2001; Kalinich et al., 2005). Studies by Gatti et al. (2004) have documented nanometer-scale particles containing toxic metals (i.e. tungsten,…
Tissue Engineering
Embryonic stem cells as a cell source for tissue engineering Ali Khademhosseini, … Robert Langer, in Principles of Tissue Engineering (Fifth Edition), 2020 Directed differentiation In cell culture, hESCs can spontaneously differentiate into cells of the three germ layers [82]. Perhaps, the biggest challenge in…